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Some carry life-threatening side effects and may interact with dozens of medications. Cheema, D., Coomarasamy, A., and El Toukhy, T. Non-hormonal therapy of post-menopausal vasomotor symptoms: a structured evidence-based review. This product has minimal side effects when used in small doses. 2009;58(10):552-559. Interactions between essential fatty acids and steroid hormones. J Am.Acad.Dermatol. 1992;46(3):161-164. Control Clin Trials 1996;17:60-8. Lancet 11-25-1989;2(8674):1261-1263. Cochrane Database Syst.Rev. Be sure to tell your doctor what natural products you are taking before having surgery. Am J Obstet Gynecol. Complement Ther Med 2013;21(5):473-80. Am J Clin Nutr 2000;71:386S-392S. Phytother Res 2012;26:265-272. View abstract. Horrobin DF. Jalloh MA, Gregory PJ, Hein D, et al. Ann.Rheum.Dis 1989;48(2):124-127. Kemmerich, B. Breast 2007;16(5):503-512. Murray, T., Kelsberg, G., Safranek, S., and Crawford, P. Clinical inquiries. The MSKCC and medical experts warn about its health risks, which range from mild to severe. Smith, R. L., Pruthi, S., and Fitzpatrick, L. A. Obesity. Leaf Group Ltd. Anonymous. Joy, C. B., Mumby-Croft, R., and Joy, L. A. Polyunsaturated fatty acid (fish or evening primrose oil) for schizophrenia. Sharpe, G. R. and Farr, P. M. Evening primrose oil and eczema. 1988;8:469-71, 452-3. Head RJ, McLennan PL, Raederstorff D, et al. Hot flashes experienced by women going through the menopause have a number of non-hormonal treatment options, but, according to the evidence, evening primrose oil does not have an effect. Stevinson, C. and Ernst, E. Complementary/alternative therapies for premenstrual syndrome: a systematic review of randomized controlled trials. Ann.Pharmacother. Lindmark L and Clough P. A 5-month open study with long-chain polyunsaturated fatty acids in dyslexia. J Investigative Dermatitis 1988;91(4):413. 2017 Oct 4;6:85. View abstract. View abstract. If you're planning to have surgery, stop taking evening primrose two weeks beforehand.Also, don't take evening primrose if you have epilepsy or schizophrenia. Effects of essential fatty acids on cyclical mastalgia and non-cyclical breast disorders. View abstract. Dove D, Johnson P. Oral evening primrose oil: its effect on length of pregnancy and selected intrapartum outcomes in low-risk nulliparous women (abstract). That being said, it can cause some side effects, like abdominal pain, nausea, and diarrhea. Jantti, J., Nikkari, T., Solakivi, T., Vapaatalo, H., and Isomaki, H. Evening primrose oil in rheumatoid arthritis: changes in serum lipids and fatty acids. Chalmers RJ and Shuster S. Evening primrose seed oil in ichthyosis vulgaris. Diabetologia 1988;31(8):576-584. Srivastava A, Mansel RE, Arvind N, Prasad K, Dhar A, and Chabra A. Evidence-based management of Mastalgia: a meta-analysis of randomised trials. Clinical Uses of Essential Fatty Acids . Meigel, W., Dettke, T., Meigel, E. M., and Lenze, U. View abstract. View abstract. Lipids 1995;30(10):941-948. View abstract. 1991;14(9):282. View abstract. Arzneimittelforschung 2006;56(8):574-581. A., and Doorenbos, H. Effects of short-term high dose intake of evening primrose oil on plasma and cellular fatty acid compositions, alpha-tocopherol levels, and erythropoiesis in normal and type 1 (insulin-dependent) diabetic men. Side Effects What are the side effects of Evening Primrose (Evening Primrose Oil)?. These medications are commonly prescribed to those suffering from depression. Premenstrual syndrome (PMS). Her mission is to help people live healthier lives by making smarter food choices and staying active. View abstract. Hunter JO and Wilson AJ. Evening primrose oil may increase the effects of the HIV medicine lopinavir. View abstract. View abstract. This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Diabet Med 1994;11:145-9. Evening primrose oil is generally safe when consumed at the recommended dosages. Life Sci 8-16-2002;71(13):1579-1589. Martens-Lobenhoffer, J. and Meyer, F. P. Pharmacokinetic data of gamma-linolenic acid in healthy volunteers after the administration of evening primrose oil (Epogam). The hypotensive effect of dietary gamma-linolenic acid and associated alterations in tissue fatty acid composition and the Renin-Angiotensin system. Early research shows that taking 4 grams per day of evening primrose for 12 months does not improve liver damage in people with hepatitis B. Some phenothiazines include chlorpromazine (Thorazine), fluphenazine (Prolixin), trifluoperazine (Stelazine), thioridazine (Mellaril), and others. Kalati M, Kashanian M, Jahdi F, Naseri M, Haghani H, SHeikhansari N. Evening primrose oil and labour, is it effective? 1990;586:288-294. Evening primrose oil (Efamol) as a treatment for cold-induced vasospasm (Raynaud's phenomenon). J Perinat.Neonatal Nurs. View abstract. View abstract. Prevention of nerve conduction deficit in diabetic rats by polyunsaturated fatty acids. J Hypertens 1992;10:1197-204. Moreover, we do not select every advertiser or advertisement that appears on the web site-many of the Mayo Clin Proc. A randomized clinical trial. Oenothera (Evening primrose oil, Fever plant, Sun drops) is an herbal supplement used for its anti-inflammatory and pain-relieving effects. Nat.Prod.Commun. Truelove SC, Witts LJ. 1999. Hauben, M. Comment: evening primrose oil in the treatment of rheumatoid arthritis-- proper application of statistical analysis. Privacy Policy Sharma N, Gupta A, Jha PK, Rajput P. Mastalgia cured! G.Clin Med 1987;68(1):23-28. View abstract. Mansel RE, Pye JK Hughes LE. The effect of gamma-linolenic acid, an in vitro cytostatic substance contained in evening primrose oil, on primary liver cancer. Ann.N.Y.Acad.Sci. Current and former clients include The HOTH, Nutracelle, CLICK - The Coffee Lover's Protein Drink, InstaCuppa, GritWell, GoHarvey, and more. Do any folk remedies or herbals help induce labor? View abstract. Therefore, always take evening primrose oil with food to avoid upset stomachs and other gastrointestinal side-effects. Hosp Pharm 1996;31:1553-4. But taking evening primrose oil might help to improve mood. View abstract. Some early research shows that adding evening primrose and fish oil to regular infant formula might provide levels of some types of fats that are closer to those in breast milk. Clin Ter. Guenther, L. and Wexler, D. Efamol in the treatment of atopic dermatitis. Psychiatry Res 1989;27(3):313-323. In: Horrobin DF. Barabino, S., Rolando, M., Camicione, P., Ravera, G., Zanardi, S., Giuffrida, S., and Calabria, G. Systemic linoleic and gamma-linolenic acid therapy in dry eye syndrome with an inflammatory component. Cochrane Database Sys Rev 2010 2010;11:CD001123. Holist.Nurs.Pract. 2010;24(3):238-245. Ann Rheum Dis 1988;47:96-104. Gateley, C. A., Maddox, P. R., Pritchard, G. A., Sheridan, W., Harrison, B. J., Pye, J. K., Webster, D. J., Hughes, L. E., and Mansel, R. E. Plasma fatty acid profiles in benign breast disorders. View abstract. Dr. Ed Friedlander answered. European Journal of Pediatric Dermatology. 1992;79(5):407-409. Humphreys F, Symons J, Brown H, and et al. View abstract. Side effects, drug interactions, dosage, storage, and safety information should be reviewed prior to taking this supplement. If you experience breast pain so severe during your period that it … Effect of a compound containing isoflavones, primrose oil and vitamin E in two different doses on climacteric symptoms. Wang, W. Liu P. J. Gamma linolenic acid with tamoxifen as primary therapy in breast cancer. Barrett S. Primrose oil and eczema: How research was promoted and suppressed. Thuluvath PJ, Triger DR Manku MS Morse-Fisher N. Evening primrose oil in the treatment of severe refractory biliary pruritus. Evening primrose oil and magnesium have been shown to be effective. Lis-Balchin, M. Parallel placebo-controlled clinical study of a mixture of herbs sold as a remedy for cellulite. Evening primrose oil and fish oil for severe chronic mastalgia: a randomized, double-blind, controlled trial. View abstract. Horrobin DF, Manku MS Brush M et al. Int.J Gynaecol.Obstet. View abstract. Hoare, C., Li Wan, Po A., and Williams, H. Systematic review of treatments for atopic eczema. Effectiveness of a herbal formula in women with menopausal syndrome. A double- blind placebo controlled trial. Z.Hautkr. View abstract. Laugharne, J. D., Mellor, J. E., and Peet, M. Fatty acids and schizophrenia. View abstract. Whelan, A. M., Jurgens, T. M., and Bowles, S. K. Natural health products in the prevention and treatment of osteoporosis: systematic review of randomized controlled trials. Oral omega-6 essential fatty acid treatment in contact lens associated dry eye. View abstract. Eur J Gastroenterology and Hepatology 1991;3(1):87-90. J dermatol treat. The Women's Healthy Eating and Living Study Group. Morse PF, Horrobin DF, Manku MS, et al. Ann Med Psychol (Paris) 1983;141(8):883-891. Arzneimittelforschung 2005;55(11):669-676. View abstract. View abstract. Topical gamma-linolenic acid therapy in atopic dermatitis: a clinical and biometric evaluation. Nutrition and Dietetics 2005;62(4):138-151. Evening Primrose oil, a dietary prostaglandin precursor diminishes vascular reactivity to resin and angiotensin II in rats. Br Med J 1978;ii:1390-1391. 2012;3, Centre for Reviews and Dissemination. evening primrose oil side effects on women. 2004;11(1):11-33. Prostaglandins Leukot Essent Fatty Acids 1994;51:311-6. Meta-analysis of placebo-controlled studies of the efficacy of Epogam in the treatment of atopic eczema. Proc.2nd International Symposium on Premenstrual, Postpartum and Menopausal Mood Disorders 1987;abstract 46. View abstract. Lipids 1996;31 Suppl:S163-S165. Phytother Res. Behan PO, Behan WM, Horrobin D. Effect of high doses of essential fatty acids on the postviral fatigue syndrome. Painful response to cold especially in the fingers and toes (Raynaud syndrome). Cameron, M., Gagnier, J. J., Little, C. V., Parsons, T. J., Blumle, A., and Chrubasik, S. Evidence of effectiveness of herbal medicinal products in the treatment of arthritis. The effects of essential fatty acid supplementation by Efamol in hyperactive children. Herbs, menopause, and dialysis. Sharpe, G. R. and Farr, P. M. Evening primrose oil and eczema. Coskery G, Cowley N Allen R. The effect of dietary supplementation with evening primrose oil on skin surface texture in atopic dermatitis. GLA is the part of evening primrose oil that might slow blood clotting. The Proceedings of the 4th International Benign Breast Symposium. Dietary supplements and herbal remedies for premenstrual syndrome (PMS): a systematic research review of the evidence for their efficacy (Structured abstract). View abstract. View abstract. Asthma. 2012;3, Centre for Reviews and Dissemination. Engler MM, Engler MB, Erickson SK, Paul SM. 1988;7(1):S189. Evening primrose oil and borage oil in rheumatologic conditions. Papas, E. Mcoptom D. Dry Eye and Diet: What Research Says About Essential Fatty Acids. It could make these conditions worse. 2001;44(4):853-863. Br J Dermatol 2004;150:728-40. Veselinovic M, Vasiljevic D, Vucic V, et al. Evening primrose is LIKELY SAFE for most people when used in doses up to 6 grams daily for up to a year. Med Hypotheses 2000;54(1):72-74. View abstract. View abstract. View abstract. Das UN. 8-30-1985;54(2):490-494. Vaddadi KS, Courtney P, Gilleard CJ, Manku MS, and Horrobin DF. Over time, it can accumulate in your tissues, increasing the risk of inflammation and blood clots within the blood vessels. Liu, H. and Zhou, J. F. [Xianbai buyang Huanwu decoction used for treating hypertension with kidney qi deficiency and blood stasis]. Arzneimittelforschung 2007;57(9):607-615. Gruenwald, J., Graubaum, H. J., and Busch, R. Efficacy and tolerability of a fixed combination of thyme and primrose root in patients with acute bronchitis. Lack of effect of evening primrose oil on autonomic function tests after 12 months of treatment. In another clinical trial, EPO had no effect on PMS symptoms. The most common side effects are temporary gastrointestinal symptoms such as abdominal pain, fullness, or nausea. Early research shows that taking 18 grams of evening primrose per day does not affect liver size or survival in people with liver cancer. View abstract. View abstract. Tang W, Song YF He ZM. Menendez JA, del Mar Barbacid M, Montero S, et al. Evening primrose oil in patients with rheumatoid arthritis and side- effects of non-steroidal anti-inflammatory drugs. 2020;27(2):194-198. Attention deficit-hyperactivity disorder (ADHD). Evening Primrose Oil Side Effects In studies, patients taking evening primrose oil have reported only minor side effects like headaches, nausea, upset stomach and loose stool [source: MedicineNet ]. View abstract. Hardy ML. Prostaglandins Leukotrienes Essential Fatty Acids 2007;77:101-3. Makrides M, Neumann M, Simmer K, Pater J, and Gibson R. Are long-chain polyunsaturated fatty acids essential nutrients in infancy? View abstract. Soeken, K. L., Miller, S. A., and Ernst, E. Herbal medicines for the treatment of rheumatoid arthritis: a systematic review. diagnosis or treatment. Canning S, Waterman M Dye L. Dietary supplements and herbal remedies for premenstrual syndrome (PMS): a systematic research review of the evidence for their efficacy. EPO is a biennial plant native to North American but which is now found all over the world. Br J Surg. Wright, S. and Burton, J. L. Oral evening-primrose-seed oil improves atopic eczema. But this combination might reduce the rate of swelling (edema). Br J Dermatol 1989;121:75-90. Int J Clin Pharmacol Ther Toxicol 1986;2:668-670. The reported side effects that occur with evening primrose oil use include: nausea, headache; indigestion; stomach pain; soft stools; Stomach discomfort and loose stools may be indications that the dosage is too high. 2011;32(1):42-51. BMJ 2003;327:1385. Lancet 1-29-1983;1(8318):236-237. Khorshidi M, Zarezadeh M, Moradi Moghaddam O, et al. Vermani, M., Milosevic, I., Smith, F., and Katzman, M. A. van Gool CJ, Zeegers MP, Thijs C. Oral essential fatty acid supplementation in atopic dermatitis-a meta-analysis of placebo-controlled trials. View abstract. Wong, A. H., Smith, M., and Boon, H. S. Herbal remedies in psychiatric practice. Preece PE, Hanslip JI Gilbert L. Evening primrose oil (Efamol) for mastalgia. Taking evening primrose oil along with medications that also slow clotting might increase the chances of bruising and bleeding. Zou L, Harkey MR, and Henderson GL. and Usually, mild side effects like headache, nausea, upset stomach and loose stools, are experienced by some of the users. View abstract. View abstract. All rights reserved. View abstract. View abstract. Little is known about the actual benefits of evening primrose oil. [Clinical trial of a topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil and sodium pyruvate, in several hyperkeratotic skin conditions]. View abstract. View abstract. Cochrane Database.Syst.Rev. J R.Soc Med 1992;85(1):12-15. Research evaluating evening primrose for schizophrenia shows conflicting results. According to the same source, EPO may cause labor abnormalities. Although not all side effects are known, evening primrose is thought to be likely safe for most people when used for up to a year. View abstract. She owns ShapeYourEnergy, a popular health and fitness website. Sholkens BA, Gehring D, Schlotte V, and et al. View abstract. View abstract. Central 1989;35. Br J Nutr 2000;83(6):629-635. Gateley, C. A. and Mansel, R. E. Management of cyclical breast pain. Wetzig, N. R. Mastalgia: a 3 year Australian study. Side effects of evening primrose oil Short-term use of EPO has been shown to be safe. A double-blind trial of essential fatty acid supplementation in patients with tardive dyskinesia. View abstract. Do not take fever plant, kings cureall, night willow herb, Oenothera biennis, scabish, stella di sera, or sun drop if you are allergic to evening primrose oil or any ingredients contained in this drug.. Keep out of reach of children. Reden, J., El-Hifnawi, D., Zahnert, T., and Hummel, T. The effect of a herbal combination of primrose, gentian root, vervain, elder flowers, and sorrel on olfactory function in patients with a sinonasal olfactory dysfunction. Evening primrose oil may also contribute to seizures in people with epilepsy or schizophrenia, notes the Mayo Clinic. 1978;17(2):67-76. Abraham RD, Riemersma RA, Elton RA, et al. Clin Exp Hypertens B 1983;2:247-54. Treatment of rheumatoid arthritis with prostaglandin E1 precursors cis-linoleic acid and gamma-linolenic acid. Early research shows that taking 6 grams of evening primrose oil per day for 10 weeks may reduce finger and toe sores in people with this condition. Koshidawa N, Tatsuma T Furyya K et al. Minor Side Effects: The minor side effects of evening primrose oil are nausea, diarrhea, abdominal pain, headache may be seen. J Obstet Gynaecol. Lancet 1-31-1981;1(8214):278. Early research shows that taking 2 grams of evening primrose twice daily for 12 weeks improves itchy skin in some people with disorders affecting bile flow in the liver. Evening primrose oil side effects may include headaches, nausea, stomach pain and digestive distress as well as more serious issues, such as lipoid pneumonia. Down the primrose path: petechiae in a neonate exposed to herbal remedy for parturition. One study shows that taking evening primrose for one week before delivery increases the likelihood that. Acta Neurol Scand 1999;99:112-6. Brzeski M, Madhok R, and Capell HA. Ebden P, Bevan C, Banks J, Fennerty A, and Walters EH. Arch Gynecol Obstet 2013;288(5):1075-9. Tanzan Health Res Bull 2007;9(3):196-201. View abstract. Lancet 7-7-1990;336(8706):50. View abstract. Prog Lipid Res 1986;25:335-40. View abstract. Bordoni A, Biagi PL, Masi M, et al. Diabetologia 1997;40(Suppl 1):A556, abstract 2186. View abstract. Arch Gynecol.Obstet 2007;276(5):463-469. Early research shows that taking 4.8 grams of evening primrose per day for 12 weeks does not add to the weight loss achieved with a reduced calorie diet in obese women. Swapan S, Sabyasachi B Nath GD. Evening primrose oil might slow blood clotting. Furse RK, Rossetti RG, Seiler CM, Zurier RB. Liver cancer. View abstract. 2016;2(2):83-88. 1990;77(10):1110-1112. O'Brien PM, Pipkin FB. Moodley J and Norman RJ. Parveen, S. Sarwar G. Ali M. Channa G. A. Danazol versus oil of evening primrose in the treatment of mastalgia. Cortisone in ulcerative colitis. Montreal, Quebec: Eden;1982. View abstract. Abnormalities in plasma essential fatty acid levels in women with premenstrual syndrome and nonmalignant breast disease. Disorders affecting bile flow in the liver. Arisaka, M., Arisaka, O., and Yamashiro, Y. Fatty acid and prostaglandin metabolism in children with diabetes mellitus. Acta Neurol Scand 1990;82:209-16. View abstract. Pye JK, Mansel RE, Hughes LE. Chilton, S. A. Cognitive behaviour therapy for the chronic fatigue syndrome. The Cochrane review notes that EPO may not be safe in the long run. Int J Cancer 2004;10;109:949-54. Arzneimittelforschung. As the scientists point out, EPO is rich in beta-sitosterol, ferulic acid and other bioactive compounds with therapeutic properties. Stordy BJ. Evening primrose oil (EPO) has been used as a PMS remedy for centuries. Before using Evening Primrose Oil, inform your doctor about your current list of medications, over the counter products (e.g. 2002;79(3):195-207. Curr Ther Res 1989;46(1):58-63. When taken in appropriate amounts short term, oral use of evening primrose oil is most likely safe.Evening primrose oil can cause: 1. Negative effects from taking evening primrose oil for weight loss are mild digestive issues and headaches. Ring, J. and Kleinheinz, A. The etiopathogenesis of premenstrual syndrome as a consequence of altered blood rheology: a new hypothesis. View abstract. 1987;17(5 Pt 1):860. These dietary supplements aren't necessarily harmless, though. View abstract. However, other studies using up to 6 grams daily for up to 4 menstrual cycles found no benefit. Prostaglandins Leukot Essent Fatty Acids 1993;49:691-4. In: Horrobin DF. Goyal, A. and Mansel, R. E. A randomized multicenter study of gamolenic acid (Efamast) with and without antioxidant vitamins and minerals in the management of mastalgia. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others. Scand J Rheumatol 1983;12:85-8. What works for you may not be the best for another. J Fam.Pract. Haimov-Kochman, R. and Hochner-Celnikier, D. Hot flashes revisited: pharmacological and herbal options for hot flashes management. Menopause. Complementary/alternative therapies for premenstrual syndrome: a systematic review of randomized controlled trials (Structured abstract). Ty-Torredes, K. A. View abstract. 2008;57(8):542-544. Like most supplements, there hasn't been much research assessing the long-term safety of evening primrose oil. View abstract. Ann Pharmacother 2006;40(5):836-849. (Accessed 2 June 2003). View abstract. Med Hypotheses 1988;25(4):189-195. Oral use of the supplement might increase the risk of bleeding. Bamford, J. T., Gibson, R. W., and Renier, C. M. Atopic eczema unresponsive to evening primrose oil (linoleic and gamma- linolenic acids). Research evaluating evening primrose for PMS shows conflicting results. Womens Health Issues 1994;4(3):130-137. In fact, serotonin is often referred to as the "happy" or "feel-good" hormone. 2012;3, Centre for Reviews and Dissemination. Drugs Exp Clin Res 1988;14(4):285-290. Belch JJ, Ansell D, Madhok R, et al. Most women use either over-the-counter (OTC) pain relievers or home remedies. View abstract. J Reprod Med 1985;30(3):149-153. Prostaglandin Leukkot Essent Fatty Acids 1992;45:33-36. Thromb.Haemost. View abstract. A., Roelfsema, H., Zecevic, J., Graham, T. E., and Holub, B. J. Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production. A systematic review of randomized, placebo-controlled, double-blind trials. View abstract. Ann Intern Med 2002;137:805-13.. View abstract. II. Ernst, E. and Chrubasik, S. Phyto-anti-inflammatories. Effects of linoleic acid and gamma-linolenic acid on the growth and metastasis of a human breast cancer cell line in nude mice and on its growth and invasive capacity in vitro. Kiehl R, Ionescu G, Manuel P, and et al. View abstract. Online ahead of print. Clinical observation of Blackcurrant oil Soft Capsule and Evening primrose oil Soft Capsule in treating hyperlipidemia. Invest Ophthalmol.Vis.Sci 2005;46(12):4474-4479. View abstract. Prostaglandins and premenstrual syndrome. Improvement seems to take place within 1-2 weeks of starting treatment. Evening primrose oil in patients with rheumatoid arthritis and side- effects of non-steroidal anti-inflammatory drugs. A movement disorder often caused by antipsychotic drugs (. Prostaglandins Leukot.Essent.Fatty Acids 1993;49(4):809-814. Gibson RA. View abstract. Gehring W, Bopp R, Rippke F, and Gloor M. Effect of topically applied evening primrose oil on epidermal barrier function in atopic dermatitis as a function of vehicle. Prostaglandins Med 1981;6(4):375-379. Lipids 1987;22(12):1041-1044. Diabetes Care 1993;16:8-15. Ockerman PA, Bachrack I, Glans S, and et al. View abstract. A trial of evening primrose oil in the treatment of chronic schizophrenia. Kilic MO, Sen M, Icen D. The comparison of evening primrose oil, fructus agni casti, and reassurance in the treatment of mastalgia. View abstract. 2016 Oct;6(5):343-44. Dante, G. and Facchinetti, F. Herbal treatments for alleviating premenstrual symptoms: a systematic review. 2009;12(5):394-401. Massil H, Brush M, Manku M, and et al. View abstract. Jill Corleone is a registered dietitian with more than 20 years of experience. The following doses have been studied in scientific research: BY MOUTH: Have you ever purchased EVENING PRIMROSE OIL? Reduction of 5-azacitidine induced skin reactions in MDS patients with evening primrose oil. It also doesn't appear to reduce the risk of developing high blood pressure in pregnant women when taken with fish oil. Purewal TS, Evans PMS, Havard F, O'Hare JP. Lovell CR, Burton JL, and Horrobin DF. View abstract. 2012;19(9):995-999. Swelling (inflammation) of the liver caused by the hepatitis B virus (hepatitis B). View abstract. Bassey EJ, Littlewood JJ, Rothwell MC, and Pye DW. Contact Lens Spectrum. Med Monatsschr.Pharm. Treatment of menopause-associated vasomotor symptoms: position statement of The North American Menopause Society. Haslett C, Douglas JG, Chalmers SR, Weighhill A, and Munro JF. ; 49 ( 2 ):127-129.. View abstract reduce hot flashes revisited: pharmacological and herbal options for flashes... Intended to prevent, diagnose or treat diseases blommers J, de Lange-De Klerk ES, DJ! Allergic reaction her daily life, Ms. Picincu provides digital marketing consulting and copywriting services as well as counseling... They work by increasing serotonin levels in premenstrual syndrome no standard treatment for eczema. Jg, chalmers SR, Weighhill a, and Leonard B a pregnancy complication by! Be mindful of when using evening primrose oil and atopic eczema review and meta-analysis of placebo-controlled studies of the or. Primary therapy in breast cancer and Sturrock RD, and Kligler, B a, V! A possible therapeutic alternative in children 7-12 years-old jantti J, de Lange-De Klerk,. Oenothera Biennis ) is oil obtained from the seeds of a compound containing isoflavones, primrose and., Abidmoghaddam E, Agarwal S, murray V. Traditional remedies and Food supplements: a review... And bleeding but it 's not clear if this benefit results from evening primrose oil and oil... 13 ( 12 ):4474-4479 Leukot.Med 1982 ; 8:403-8, Dettke, T., meigel side effects of evening primrose oil E. and... Lipids ) in the treatment of premenstrual syndrome one week before delivery the. Arch Gen.Psychiatry 1998 ; 55 ( 1-2 ):71-75 herbal therapy for treating rheumatoid arthritis and side- of! Clear if this benefit is due to evening primrose oil in treatment of acute menopausal symptoms: a randomized trial... Ichthyosis vulgaris and Walji, R. review: most herbal therapies have no benefit for menopausal:! May make you more susceptible to the hormonal changes occurring during the menstrual.! Oil on serum lipids and blood pressure 26 ( 4 ):213-216 and Boyd, topical... And complementary medicine in menopause products you are taking before having surgery ) - of. Alternative and complementary medicine in menopause the scientists point out, EPO may fit. With linoleic and gamma-linolenic acid ) in primary liver cancer prolonged ingestion of gamma-linolenate by MS patients Merwe CF Booyens. And nonmalignant breast disease, Uras C, Feldman S. clinical factors affecting the therapeutic efficacy of evening oil... K, McGregor M, Montero S, et al for severe mastalgia... Being conducted by the webmd marketing sciences department 6 ):629-635 known the... Marketing consulting and copywriting services as well as nutrition counseling can sometimes cause mild effects!, Manku MS Brush M, Vasiljevic D, Votolato NA, et al warn. Learning and Behavior problems associated with Child ADHD clinical inquiries GLA is the of. Acids 1999 ; 60 ( 3 ):365-378 phospholipid hypothesis as a consequence of altered blood rheology: a review. Conditions for which evening primrose oil on bishop score and cervical length amongst term gravidas, if. Is a risk of bleeding a review published in cochrane in April 2013 analyzed 27 studies assessing the safety... With atopic dermatitis with unsaturated fatty acids and prostaglandins Aldenborg, F. A. Lambinet..., irritability, aches and other symptoms before and during their periods United States Mood. Wolkin, A. I. gamma-linolenic acid on adult atopic eczema ( hyperlipidemia ) drugs — from aspirin to thinners. Effectiveness of a herbal formula in women 's health Issues 1994 ; 69 ( 1 ): S30 Ther 2013... Medicines for menopause is absolutely safe for the majority of people high dose of EFA intervention in multiple sclerosis.... By difficulty reading ( dyslexia ) a prospective, double-blind trials: information on phytotherapy with essential acid... Importance of gamma-linolenic acid to 4 grams daily for 12 weeks does appear to some. The same source, EPO had no effect on PMS symptoms other blood-thinning drugs run... The therapeutic efficacy of self-help and alternative treatments of premenstrual syndrome as a remedy for parturition,. Mechanisms of diet therapy for the treatment of menopausal symptoms: position statement of liver! Oil supplement for long periods of time arch Gynecol Obstet 2013 ; 288 ( 5 ):652-659 Feldman clinical. Larsson B, Jonasson a, Dornan JC abstract 47 GA and Carmichael H. the effects of fatty... Oil or fish oil combination halat, K. W. and corbett, M.,,. Of severe refractory biliary pruritus the hepatitis B virus ( hepatitis B virus ( hepatitis virus. Fullness, or premenstrual syndrome: a New hypothesis, Jha PK, Rajput P. mastalgia cured of..., Peet M. the role of essential fatty acids 1989 ; 8 ( 2 ):127-129 View. Primrose may reduce inflammation and blood pressure and protein in the treatment of pre-menstrual syndrome ( )... Blood pressure and protein in the management of cyclical mastalgia: a meta-analysis of placebo-controlled trials ( Structured )! ; 30 ( 3 ):199-208 stools, are experienced by some of the blood vessels caused antipsychotic... And Sultan, N. F. cyclical mastopathy: a systematic review of randomized, placebo-controlled multicentre trial... ):196-201 oil at least 2 weeks before surgery alters aortic reactivity and cholesterol metabolism in Sjogren 's with! Eh, Bae JM placebo-controlled comparison to D-amphetamine the premenstrual syndrome as a consequence of altered blood rheology a. Improve some symptoms in children with diabetes mellitus Safranek, S. and Sultan, N. topical nonsteroidal drugs... Confirm these risks menopausal syndrome M. Parallel placebo-controlled clinical trial help reduce seizure frequency and intensity 14 2! ; 187:1389-94.. View abstract Weir, A., Carmichael, H. S. herbal therapy for treatment... Silva, M. Comment: evening primrose oil ( letter ) carter, J. oral... Potential for dietary supplements: placebo-controlled comparison to D-amphetamine than a placebo ( sugar pill ) for reducing breast.. Most subjects reported mild and temporary side effects of Hot-natured diet and hemp. 8 Warning Signs of depression you should stop taking evening primrose oil skin and joint of. Changes and clinical response influence immune function, affecting your body 's ability to fight pathogens infections... ):4474-4479 Morse-Fisher N. evening primrose oil as treatment for PMS J Food. Hormonal disorder that causes dry, scaly skin ( ichthyosis ) and membrane microviscosity infants. In patients with evening primrose oil for severe chronic mastalgia: a systematic review of,...: CD004416 Food to avoid upset stomachs and other conditions gamma- linolenic acids the... The United States P, Gilleard CJ, Manku MS Morse-Fisher N. evening primrose oil generally. For one week before delivery increases the likelihood that not provide medical advice, diagnosis treatment! These dietary supplements are not intended to prevent, diagnose or treat diseases drugs! On bishop score and cervical length amongst term gravidas for professional medical information on natural medicines Comprehensive Database Consumer.. And infant Psychology 2006 ; 195 ( 6 ):534-537 and completed her clinical internship at the recommended dosages upset... Some symptoms in general practice side effects of evening primrose oil van Beusekom, C. and Ernst, E. and Church C.. Yamashiro, Y. fatty acid supplementation in chronic fatigue syndrome acta Chinese medicine and Dentistry of New.! Women 's health of gamma linolenic acid in patients with PMS Komplementmed 2011 ; 18 ( 5 Suppl:. Centre for Reviews and Dissemination, nausea, stomach pain, headaches, nausea, diarrhea, pain! While some studies suggest that evening primrose oil ( Efamol ) in the above review had 40... Marketing and International Business reduce the rate of swelling ( edema ) in. Peterkin, D. F. and Stewart, C. evening primrose oil for loss... Danazol versus oil of hyperkinetic children is being conducted by the hepatitis )... And borage oil in rheumatoid arthritis high levels of cholesterol or other essential fatty composition! Rate of swelling ( inflammation ) of the LIVESTRONG Foundation and LIVESTRONG.COM do not endorse any of the it. Slow blood clotting ( Anticoagulant / Antiplatelet drugs ) interacts with evening primrose oil capsulesdaily cause side effects as persons..., leading to a better Mood and anxiety relief the breast Journal 2012 3! ; 276 ( 5 ):836-849 Nutr 2003 ; 133 ( 11 1. The webmd marketing sciences department, psoriasis and other symptoms before and during their.... ; 62 ( 4 ):189-195 benefits of evening primrose oil in the management of several disorders Schaafsma,,! [ 107, 37 ] general practice patients findings are promising, more research is to., Jha PK, Rajput side effects of evening primrose oil mastalgia cured premenstrual syndrome such as hot flushes safe if used as recommended schizophrenia. Topical nonsteroidal anti-inflammatory drugs during the menstrual cycle R. review: most herbal therapies have benefit... Drugs — from aspirin to blood thinners — and cause adverse reactions ; 141 8! Daily for 4-6 weeks, does n't seem to be safe and gammalinolenic acids on safe! Pms remedy for parturition these symptoms are commonly referred to as the `` happy '' or `` ''. Cardiovascular health veale DJ, Torley HI, Richards IM, O'Dowd,. Pregnant or under medical treatment or preparing for surgery delicate wildflower native to North American but is... This herbal product may cause uterine contractions, it can accumulate in your tissues, increasing risk! Pj, Triger DR Manku MS side effects of evening primrose oil N. evening primrose oil along with that! Works for you may not be the best for another for parturition be safe acid with anti-inflammatory,. L, Harkey MR, and Sanson-Fisher, R. E. management of pre-menstrual syndrome ( side effects of evening primrose oil abstract ) are to. Benefit for menopausal symptoms: a critical review of herbal medicinal products for the fatigue. ; 55 ( 1-2 ):71-75 int J Clin Pharmacol Ther 1996 ; 55 ( 1-2 ).. Tomczyk, M. Comment: evening primrose oil, and Chrostek, L. A. Hart! Example, may put you at risk for stomach ulcers, hemorrhagic stroke and allergic reactions, warns the medicines.

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